Clinical evidence which investigated the effects of l-carnitine, a vitamin-like substance, on weight loss had led to inconsistent results. This study therefore aimed to examine the effect of l-carnitine supplementation on body weight and composition by including the maximum number of randomized controlled trials (RCTs) and to conduct a dose-response analysis, for the first time.
Methods and results: Online databases were searched up to January 2019. In total, 37 RCTs (with 2292 participants) were eligible. Meta-analysis showed that l-carnitine supplementation significantly decreased body weight [Weighted mean difference (WMD) = -1.21 kg, 95% confidence interval (CI): -1.73, -0.68; P < 0.001], body mass index (BMI) (WMD = -0.24 kg/m2, 95% CI: -0.37, -0.10; P = 0.001), and fat mass (WMD = -2.08 kg, 95% CI: -3.44, -0.72; P = 0.003). No significant effect was seen for waist circumference (WC) and body fat percent. The meta-analysis of high-quality RCTs only confirmed the effect on body weight. A non-linear dose-response association was seen between l-carnitine supplementation and body weight reduction (P < 0.001) suggesting that ingestion of 2000 mg l-carnitine per day provides the maximum effect in adults. This association was not seen for BMI, WC and body fat percent.
L-carnitine is an amino acid, it’s actually more of a vitamin-like substance that plays a number of roles in your body. It’s formed in your liver and kidneys and made from two essential amino acids (lysine and methionine). Some medical professionals prescribe L-carnitine in supplement form to help support those with heart conditions, diabetes, erectile dysfunction, and other health conditions. But because of its role in fat metabolism, it’s best known for its ability to aid in weight loss, particularly when combined with a healthy diet and exercise routine.
L-carnitine plays an essential role in the transportation of fats to the mitochondria, where they’re converted to energy. There’s a whole lot of science to it, of course, but to keep it simple, we’ll put it this way: L-carnitine could very well be the answer to your weight loss dreams. Take a look below at 5 benefits of L-carnitine weight loss supplement and how it can help you shed pounds both directly and indirectly.
1. L-carnitine burns fat
With higher levels of L-carnitine, your body becomes more efficient at burning fat. Not only does this decrease the amount of fat that your body stores, but it also helps reduce visceral belly fat, the kind that surrounds your vital organs and potentially leads to fatty liver disease and other serious health conditions.
2. More energy during and after a workout
As your body’s capacity for fat-burning rises, so does your energy level. L-carnitine not only helps you increase the amount of fat burned with every workout, but you also get more energy for better workouts and an active lifestyle.
3. L-carnitine boosts your metabolism to help you lose weight
Taking that energy increase into your exercise routine will allow you to perform with more intensity, providing a boost to your metabolism. A more efficient metabolism significantly aids your weight loss program because you’ll increase the amount of calories you’re able to burn—even at rest.
4. Enhanced recovery from an L-carnitine injection
L-carnitine helps reduce the buildup of lactic acid in your muscles. Muscle lactate buildup is responsible for pain and muscle fatigue after an intense workout. L-carnitine helps clear out the lactate so you recover more quickly and can get back to that fat-melting exercise that’s so central to your weight loss program.
5. L-carnitine aids the body’s immune system
In addition to the fat-burning and weight loss benefits of L-carnitine, it also aids the body’s immune system and functions as an effective antioxidant as well. How does this connect to your weight loss program? Easy: The better you feel, the more likely you are to put on your gym clothes on and get your body moving.
It’s important to note that L-carnitine will not help you burn fat or lose weight if you don’t combine it with a healthy diet and exercise routine. If you’ve already established a healthy routine, but it doesn’t seem to be helping you shed pounds, L-carnitine lipotropic injections might be just what you need to help increase the impact of the work you’re already doing.
Conclusions: l-carnitine supplementation provides a reducing effect on body weight, BMI and fat mass, especially among adults with overweight/obesity.
Reference: Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Nasir Talenezhad, Mohammad Mohammadi, Nahid Ramezani-Jolfaie, Hassan Mozaffari-Khosravi, Amin Salehi-Abargouei. 10.1016/j.clnesp.2020.03.008.