University of Minnesota

The University of Minnesota, Twin Cities (the U of M or Minnesota) is a public land-grant research university in the Twin Cities of Minneapolis and Saint Paul, Minnesota. The Twin Cities campus comprises locations in Minneapolis and Falcon Heights, a suburb of St. Paul, approximately 3 miles (4.8 km) apart. The Twin Cities campus is the oldest and largest in the University of Minnesota system and has the ninth-largest main campus student body in the United States, with 51,327 students in 2019–20. It is the flagship institution of the University of Minnesota System, and is organized into 19 colleges, schools, and other major academic units.

The Minnesota Territorial Legislature drafted a charter for the U of M as a territorial university in 1851, seven years before Minnesota became a state. Today, the university is classified among “R1: Doctoral Universities – Very high research activity”. Minnesota is a member of the Association of American Universities and is ranked 17th in research activity, with $954 million in research and development expenditures in the fiscal year 2018. In 2001, the University of Minnesota was included in a list of Public Ivy universities, which includes publicly funded universities thought to provide a quality of education comparable to that of the Ivy League.

University of Minnesota faculty, alumni, and researchers have won 26 Nobel Prizes and three Pulitzer Prizes. Among its alumni, the university counts 25 Rhodes Scholars, seven Marshall Scholars, 20 Truman Scholars, and 127 Fulbright recipients. The university also has Guggenheim Fellowship, Carnegie Fellowship, and MacArthur Fellowship holders, as well as past and present graduates and faculty belonging to the American Academy of Arts and Sciences, National Academy of Sciences, National Academy of Medicine, and National Academy of Engineering. Notable University of Minnesota alumni include two vice presidents of the United States, Hubert Humphrey and Walter Mondale, and Bob Dylan, who received the 2016 Nobel Prize in Literature.

Website www.umn.edu

ECP Doctoral Program Courses

ECP 5220: Regulatory Issues in Drug Research. Regulatory issues encountered in conducting drug research trials.  Performing different aspects of clinical trials.

ECP 5620: Drug Metabolism and Disposition. Oxidative/conjugative enzymes systems involved in human drug metabolism/disposition. Various in vitro models used to evaluate drug metabolism or chemical entity, pros/cons of each. Factors involved in conducting in vivo studies. Components used to predict in vivo drug disposition from in vivo studies.

ECP 8100: Seminar. Discussion of contemporary issues and research problems in the areas of experimental and clinical pharmacology.

ECP 8200: Research problems. An individually designed research experience directed at contemporary problems related to the drug use process.

ECP 8220: Experimental and Clinical Pharmacology. Theory of advanced methodologies, applications and evaluation techniques used to determine efficacy and toxicity of new drug therapies. Advanced techniques for collecting and evaluating data.

ECP 8230: Principles of Clinical Pharmacology. Factors determining drug exposure, drug receptor pharmacology, drug response. Personalized medicine including drug interactions, obesity, age (geriatrics/pediatrics), critical illness, therapeutic evaluation, drug development.

ECP 8500: Advances in Pharmacometric Modeling and Simulation.

ECP 8501: Pharmacometrics. Theory and application of contemporary methods for analysis of concentration-time data and exposure-response relationships.

ECP 8502: Introductory Pharmacokinetic Methods. Theoretical background for using a mixed effects model in a population analysis. Building fixed and random effects into a pharmacostatistical model. A project will allow the student to become familiar with a contemporary population pharmacokinetic analysis program.

ECP 8503: Intermediate Population PK/PD Methods. Present the theory and hands-on application of intermediate population methods using nonlinear mixed-effects model applied to pharmacologic systems.

ECP 8504 Modeling Biologics. Develop computer skills to apply nonlinear regression models to describe the pharmacokinetics and pharmacodynamics of biologics.

ECP 8505 Applied PBPK Modeling.  Theory and implementation of contemporary methods for analysis and implementation of contemporary methods for analysis and simulation of PBPK to support model-informed drug development.

ECP 8506: Clinical Trial Simulation. Theory/application of contemporary methods of using simulations to design more efficient/informative clinical trials.

Website www.pharmacy.umn.edu

The Department of Experimental and Clinical Pharmacology

University of Minnesota College of Pharmacy
7-115 Weaver-Densford Hall
308 Harvard St. S.E.
Minneapolis, MN 55455